Q&A: How do Roxies Affect Your Brain?


What are roxies?

Roxies are also called Roxicodone. Roxicodone, sometimes spelled “Roxycodone,” is a potent narcotic pain reliever that blocks the perception of pain by binding to opiate receptors in the brain and body. Roxycodone is recommended for treating moderate to severe pain or to sedate a patient prior to surgery. The recommended adult dose of Roxycodone can vary depending on the patient’s response, his or her weight and size and the severity of pain. Roxycodone is the brand name for oxycodone, available in immediate-release tablets. The drug Roxycodone, is an opioid, meaning that while it’s a powerful tool in the battle for pain management, it also has a tendency to be habit-forming.

How do roxies affect your brain?

When you are in pain your brain is sending off messages. Specific parts of the brain get excited and tell your body you are in pain. Roxies keep this from happening.

Roxies alter your perception and emotional response to pain by binding to opioid receptors in the central nervous system. Roxies affect the brain by acting the same way any other opioid does.

Roxies bind to specific receptors in the brain that deal with pain and pleasure. These receptors are known as mu, kappa, and delta receptors. When roxies bind to these receptors it keeps the neurons from getting excited and telling your brain you are in pain and instead tells your brain you feel good. Roxies decrease the excitability or response of those neurons and also blocks them from sending the messages of pain.

Opiate agonists like roxies do not completely alter the brain though, just the parts of the brain that perceive pain and pleasure. This is what makes them so effective. Roxies can relieve pain without causing a loss consciousness. The reason for this is because roxies alter the perception of pain in higher levels in the central nervous system as well as altering your emotional response to the pain in the pleasure centers. This is what results in the pain relief and the euphoria that many recreational users of roxies experience. This is also what makes roxies highly addictive. Especially for someone who has been taking roxies for a long period of time, they have altered their pain or opiate receptors to the point that now the brain is no longer dealing with pain on its own but is reliant on the medication. Through constant stimulation of key pleasure centers within the brain, and its reward system, opiate users are conditioned to want more of the drug.

Roxies may not affect the brain entirely, only the pain and pleasure receptors but they do affect other parts of the brain and nervous system. For instance, in addition to pain relief, roxies stop the cough reflex, slows breathing and causes the pupils to shrink. Roxies also have the ability to lower body temperature. The two biggest affects roxies have on the nervous system are:

  • Suppressed cough – Roxies are also a cough suppressant. Roxies suppress the cough reflex because they affect the cough center in the medulla. The medulla is located in the brain and controls breathing etc.
  • Respiratory depression -Roxies also cause respiratory depression or decreased breathing because it directly affects the brain stem’s respiratory centers. This is when overdose from roxies happen. Slowed breathing reduces the responsiveness of the brain stem respiratory centers. By doing this it compounds on itself and cause death.

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